Running Head: Indoxyl sulfate suppresses HIF activation through AhR
نویسندگان
چکیده
Title Page 1 2 Activation of aryl hydrocarbon receptor mediates suppression of hypoxia inducible 3 factor-dependent erythropoietin expression by indoxyl sulfate 4 5 Hirobumi Asai, Junya Hirata, Ayumi Hirano, Kazuya Hirai, Sayaka Seki and Mie 6 Watanabe-Akanuma 7 8 Safety Research Center, Kureha Corporation, 3-26-2 Hyakunin-cho, Shinjuku-ku, 9 Tokyo 169-8503, Japan 10 11 12 Running Head: Indoxyl sulfate suppresses HIF activation through AhR 13 14 Corresponding Author: Hirobumi Asai, Safety Research Center, Kureha Corporation, 15 3-26-2 Hyakunin-cho, Shinjuku-ku, Tokyo 169-8503, Japan 16 Tel.: +81-3-3362-7420; Fax: +81-3-3362-7457; e-mail: [email protected] 17 18 Articles in PresS. Am J Physiol Cell Physiol (November 11, 2015). doi:10.1152/ajpcell.00172.2015
منابع مشابه
Activation of aryl hydrocarbon receptor mediates suppression of hypoxia-inducible factor-dependent erythropoietin expression by indoxyl sulfate.
Indoxyl sulfate (IS) is a representative uremic toxin that accumulates in the blood of patients with chronic kidney disease (CKD). In addition to the involvement in the progression of CKD, a recent report indicates that IS suppresses hypoxia-inducible factor (HIF)-dependent erythropoietin (EPO) production, suggesting that IS may also contribute to the progression of renal anemia. In this report...
متن کاملPodocyte Injury Caused by Indoxyl Sulfate, a Uremic Toxin and Aryl-Hydrocarbon Receptor Ligand
Indoxyl sulfate is a uremic toxin and a ligand of the aryl-hydrocarbon receptor (AhR), a transcriptional regulator. Elevated serum indoxyl sulfate levels may contribute to progressive kidney disease and associated vascular disease. We asked whether indoxyl sulfate injures podocytes in vivo and in vitro. Mice exposed to indoxyl sulfate for 8 w exhibited prominent tubulointerstitial lesions with ...
متن کاملIndole-3-propionic acid suppresses indoxyl sulfate-induced expression of fibrotic and inflammatory genes in proximal tubular cells
Indoxyl sulfate (IS) induces fibrosis and inflammation in kidneys via oxidative stress through the induction of transforming growth factor-β1 (TGF-β1) and monocyte chemotactic protein-1 (MCP-1). Furthermore, IS is a potent endogenous agonist for aryl hydrocarbon receptor (AHR), which regulates the transcription of genes such as cytochrome P450 (CYP) 1A1. Indole-3-propionic acid (IPA) is an anti...
متن کاملThe uremic toxin 3-indoxyl sulfate is a potent endogenous agonist for the human aryl hydrocarbon receptor.
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor involved in the regulation of multiple cellular pathways, such as xenobiotic metabolism and Th17 cell differentiation. Identification of key physiologically relevant ligands that regulate AHR function remains to be accomplished. Screening of indole metabolites has identified indoxyl 3-sulfate (I3S) as a potent endoge...
متن کاملActivation of aryl hydrocarbon receptor mediates indoxyl sulfate-induced monocyte chemoattractant protein-1 expression in human umbilical vein endothelial cells.
BACKGROUND Indoxyl sulfate (IS) is a uremic toxin that causes renal injury, but little is known about its adverse effects on the cardiovascular system. The aryl hydrocarbon receptor (AhR) is a ligand-activated transcriptional factor that mediates adaptive and toxic responses in cells. Recent studies identified IS as an endogenous agonist for AhR, as well as other tryptophan metabolites. The aim...
متن کامل